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MADALIGNANTES ISHILL, N. M. (AP) — The first big drugmaker to make a generic version of Pfizer’s erectile dysfunction drug, Cialis, will be the first to stop selling the drug. The new, generic version of Viagra, the world’s best-known erectile dysfunction drug, will be marketed to men with ED and a lower risk of heart attack and stroke.

“We believe that men with ED can feel their best and most satisfying sexual life,” said Dr. Mark C. Henry, the head of drug strategy at Pfizer Inc.’s drugmaker, which makes Viagra, and co-CEO William Surowitz said in a statement.

Viagra was Pfizer’s first-ever drug to sell for erectile dysfunction, the drug’s active ingredient, sildenafil citrate. Viagra can help men get and keep an erection, but men who have a weak or blocked erection might not be able to get it, said C. J. Haddox, vice president of marketing and sales at Pfizer. Viagra helps men with erectile dysfunction with a blood flow to the penis, he said.

Viagra sales reached $1 billion last year, with sales reaching $2.5 billion in the U. S., the company said.

Originally Published: September 27, 2017 at 12:00 AM EDT

Pfizer Inc. (NYSE: PFE) has just approved a deal with rival CVS Corp. to sell Cialis, the world’s best-selling erectile dysfunction drug, to distributors in the U. S. The drugmaker, which makes the brand name Viagra, said the deal would bring the amount of money it would earn from selling Viagra to consumers in the U. to as much as $1 billion each.

CVS and its distributor will receive a share of the profits, Pfizer said. But the company said sales would be limited to about $300 million a year. Pfizer said it was considering a lower price for Viagra, but the drugmaker said it could not be certain how much it will receive from the sale.

“There’s been some criticism of the way that CVS has marketed products and the way it has marketed products,” Henry said in a statement.

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This medication is controlled by Phelans Pharmacy (Ireland) and is dispensed under the guidance of a Phelans pharmacist.

What Cialis For Men 10mg Film-coated Tablets is and What it is Used For

Cialis for men 10mg film-coated tablets is a treatment for adult men with erectile dysfunction. This is when a man cannot get, or keep a hard, erect penis suitable for sexual activity. Cialis for men 10mg film-coated tablets has been shown to significantly improve the ability to obtain a hard erect penis suitable for sexual activity.

Cialis for men 10mg film-coated tablets contains the active ingredient tadalafil which belongs to a group of medicines called phosphodiesterase type 5 inhibitors. Following sexual stimulation Cialis for men 10mg film-coated tablets works by helping the blood vessels in your penis to relax, allowing the flow of blood into your penis. The result of this is improved erectile function.

Can I buy Cialis Online in Ireland?

You can safely and conveniently buy Cialis online from Phelans Pharmacy. We understand that discussing erectile dysfunction (ED) can be uncomfortable, which is why we offer a discreet and professional online assessment to ensure Cialis (Tadalafil) is a suitable and safe treatment option for you. Our experienced pharmacists will review your assessment and determine if Cialis is the right choice for you.

Is Cialis Available Over the Counter?

Cialis is an over-the-counter medication in Ireland, meaning you do not need a prescription to purchase it. However, a consultation with a pharmacist is required before supply.

The pharmacist will have to have a telephone consultation with you before the supply of this medicine.

The maximum purchase that can be made of any brand of Cialis for men 10mg tablets is 16 tablets.If a quantity exceeding the maximum of 16 tablets of Cialis for men 10mg tablets is ordered, your balance will be refunded.

Always consult the Patient Information Leaflet before using this medication.

The sale of Cialis for men 10mg tablets is limited to the Republic of Ireland. We do not sell internationally.

Keep all medicines out of the sight and reach of children.

What are the side effects of Cialis?

Common side effects include:

  • Headache
  • Flushing (warmth, redness, or tingly sensation)
  • Indigestion or upset stomach
  • Nasal congestion
  • Temporary changes in vision or speech
  • Itching or tingling in the stomach

Suspension-Proof Cialis is not intended to be healthcare advice; it is a prescription for around The cheaper the cheaper thereal benefits of Cialis outweigh the risks. There should be a pathway to getting a prescription for Cialis without a licensed pharmacist's supervision.

REFER TO Side Effects

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All three side effects occurring in one to two hours after taking the tablet, are largely insignificant with more severe side effects being more likely.

Description

Cialis 20 mg is a medication that is used to treat erectile dysfunction (ED) in men. It is a generic version of Tadalafil, the branded version of which is also available in the U. S. and Canada.

The active ingredient in Cialis 20 mg is Tadalafil.

The tablet is taken 30 minutes to 1 hour before sexual activity. The recommended dose is one tablet a day.

It is important to note that Cialis 20 mg does not work instantly, and it can take up to 6 weeks to start working.

Cialis 20 mg is not recommended for individuals who have not responded to other ED medications. Individuals with heart conditions or those taking nitrates should also consult their doctor before using Cialis 20 mg.

Cialis 20 mg is available only with a doctor’s prescription. Do not take Cialis 20 mg if you are allergic to it, or if you have been diagnosed with an ED or have been taking nitrates for chest pain or heart disease.

Do not take Cialis 20 mg if you have had a stroke or heart attack within the past 6 months. Do not take Cialis 20 mg if you have an existing serious heart condition such as unstable angina.

Do not take Cialis 20 mg if you have recently had a heart attack or stroke.

Talk to your doctor before taking this medication if:

  • You have a serious heart condition
  • You are taking nitrates for chest pain or heart disease
  • You are taking blood thinners such as warfarin
  • You have low blood pressure
  • You have diabetes or a condition that affects blood flow to your penis
  • You are taking a blood thinner such as Coumadin or dronedarone

This product requires a prescription.

This medication may interact with other medications or supplements. Always consult your doctor or pharmacist before starting or stopping any medication.

Cialis 20 mg works for up to 36 hours, allowing for improved erectile function. This may be time enough for sexual activity to occur, but the effects last longer. It can take up to a week before sexual activity is possible. This medication may cause mild to severe side effects such as headache, dizziness, flushing, upset stomach, or nasal congestion. If you experience any severe side effects, such as chest pain, sudden vision loss, difficulty urinating, or an erection lasting more than 4 hours (priapism), seek medical attention immediately.

Do not take Cialis 20 mg if you have taken:

  • Nitrates (e.g., isosorbide dinitrate, isosorbide mononitrate)
  • Alpha blockers (e.g., terazosin, doxazosin, tamsulosin)
  • Other medications (e.g., antibiotics, antifungals, HIV protease inhibitors, HIV medications, HIV medications for AIDS)

Always read the label and follow the directions for use.

Store Cialis 20 mg at room temperature away from moisture and heat.

Do not store in the bathroom. Keep all medications away from children and pets.

Cialis 20 mg should be used with caution in older adults and those with heart conditions. Cialis 20 mg may not work as well in those with high blood pressure or certain types of leukemia.

Do not use Cialis 20 mg if you are using any other ED medications, including over-the-counter ED products.

Store Cialis at room temperature and out of children’s reach, but consult your doctor before use if you have any underlying health conditions, or are pregnant or plan to become pregnant.

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Interactions

A. Top Drug-Drug Interactions:

1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).

2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.

3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.

Other Drug-Drug interactions:

  • Ketoconazole, itraconazole (used to manage fungal infection)
  • Protease inhibitors (used to manage HIV infection) Ex. ritonavir, lopinavir
  • Phenobarbital, phenytoin, carbamazepine (medicines used for fits)
  • Rifampicin, erythromycin, clarithromycin (medicines used for bacterial infections)
  • Other medicines used to improve blood flow to the penis (Ex. sildenafil)

B. Drug-Food Interactions:

Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:

  1. Grapefruit and Grapefruit Juice: Grapefruit can increase the levels of tadalafil in your blood by interfering with its metabolism. This may amplify side effects, such as headaches, dizziness, or low blood pressure. Avoid consuming grapefruit or grapefruit juice while taking Cialis.
  2. Alcohol: Drinking alcohol with Cialis can enhance the blood pressure-lowering effects of the medication, leading to symptoms like dizziness, lightheadedness, or fainting. Limiting alcohol intake is recommended while using Cialis.
  3. High-Fat Meals: While Cialis can be taken with or without food, consuming it with a high-fat meal may delay its onset of action. Opt for lighter meals if rapid effectiveness is needed.
  4. Caffeine: Though not a direct interaction, combining Cialis with high caffeine intake might worsen side effects like headaches or increase heart rate in sensitive individuals.
The top drug-food interactions for

Cialis and the Other Drug-Drug Interactions

Nitrates (e.g., nitroglycerin, tadalafil)

For example, men with type 2IA or brPLIED low blood pressure often taking nitrates () also use nitrates, which can cause a dangerous drop in blood pressure when used with tadalafil. It is contraindicated to use Cialis with nitrates or any high-fat meal.

: Alpha-blockers can enhance the blood pressure-lowering effects of tadalafil, resulting in symptoms like dizziness, fainting, or orthostatic hypotension. If needed, your doctor may adjust the dosage or prescribe a different medication.

Other Drug-Drug Interactions:

C.

The Food and Drug Administration has approved an application to market an impotence drug containing Viagra Connect 100mg tablets.

Pfizer, the maker of Viagra, a popular treatment for erectile dysfunction, is offering the drug at a lower price than the generic version. The drug is priced at $15.

Viagra Connect 100mg is available in 30mg tablets and comes in a chewable tablet form.

Pfizer also announced the launch of a generic version of the impotence drug, which will cost $25.

The drug contains sildenafil, a drug used to treat erectile dysfunction in men. It belongs to a class of drugs known as phosphodiesterase type 5 (PDE5) inhibitors.

The FDA previously approved sildenafil, the active ingredient in Viagra, in December 2005. The drug is not available as a generic.

The FDA approved a generic alternative, which is expected to hit the market in 2027. Pfizer is looking for a discount toaler, which will be available on prescription and over-the-counter (OTC) sales at a lower price.

“This is the first time that a generic drug has been approved for sale in the U. S.,” said Janet Woodcock, the health care secretary. “It is important that our patients and patients' families be aware that these drugs can be very expensive.”

The government agency is expected to issue a public notice on January 22, 2023. It is not expected to issue a notice before the end of 2026.